IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes

IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.

T cell responses are determined by the environment in which antigen is encountered. In the absence of proper costimulation, anergizing stimuli induce the activation of a specific program of gene expression. Proteins encoded by these genes impose a state of functional unresponsiveness in anergic T cells through the activation of different mechanisms that include dampening of the T cell receptor ...

IMMUNOBIOLOGY A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD; 2Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan; 3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, 4Department of Oncology Biostatistics, and 5Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine...

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.

Tissue-derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an important negative regulator of T-cell function. In this report, we demonstrate that A(2A)R stimulation not only inhibits the generation of adaptive effector T cells but also promotes the induction of adaptive regulatory T cells. In vitro, antigen recognition in the setting of A(2A)R engagement induces...

Requirement of high-affinity IL-2-IL-2R interaction for T cell anergy induction.

Incomplete T cell antigen receptor-mediated signaling induces an unresponsive state known as anergy. Previously, we had shown that anergy can be induced in antigen-primed but not naive T cells. In this report, we found that in vitro primed T cells from IL-2R alpha-deficient mice were resistant to anergy induction in contrast to comparably treated wild-type T cells. This resistance persisted eve...

The Balance Between Donor T Cell Anergy